Food and nutritional insecurity have attracted global recognition, which is a major problem in our society, while small-holder farmers need to adopt agro-processing enterprises in order to increase the productivity of the food crops value chain. This study examined the cassava processing as a driver of agricultural enterprises in Kwara State, Nigeria. A multi-stage sampling technique was used to randomly select 120 farmers from 40 major towns/communities in ten (10) LGAs in the four (4) ADP zones of the State, which covers Kwara-Central, Kwara-North and Kwara-South senatorial districts. Structured interview schedule was used as instrument to collect primary data from respondents on their socio-economic characteristics; determine the level of awareness; adoption of cassava processing and identify the constraints affecting cassava processing enterprises in the study area. Data were subjected to descriptive statistics, profitability and multiple regression analysis. The result revealed that the majority (65.4%) of the processors/farmers were between 30-55 years with a mean age of 42 years; (66.67%) were females, with 85 percent married; while (67.49%) were educated. The majority (45%) had household sizes of between 3-10 members with over 10 years of experience, and engaged in different occupations, while 39.17 percent sourced their funds from cooperative groups for cassava processing enterprises, and more than half (37.5%) were into gari processing enterprises. The cassava processing enterprises in the study area are profitable (N 162, 750) with low income. The major constraints faced by the processors were high cost of transportation (18.33%), poor pricing and marketing of cassava information (16.66%), inadequate capital (14.16%), government policies and institutional support (9.16%). The study recommended that Government and development partners need to consider a project or policy that will inspire youths to venture into cassava processing enterprises, implements an effective pricing policy; extends the cassava buy-back policy and organizes farmers into virile cooperatives while research institutions like NCAM, NSPRI, etc. should intensify works on mechanical gari fryers, cassava chipping machine and pressurized hydraulic presser for better profit maximization