Following the difficulties experienced by patients in getting quality health care services in Jos Metropolis, this study investigated the effects of nursing care and gender on health locus of control among patients in selected private and public hospitals in Jos Plateau State. 195 patients, 99 males and 96 females took part in the study. Their ages ranged from 16 to 55 years with a mean of 10. 53 and standard deviation of 3.29. The Multi Health Locus of control Scale (Wallston and Wallston 1978) and the perceived Quality of Nursing Care Scale (PQNCS) Leinenen, Leinokilpi and Stalberg, (2001), were used to measure health locus of Control and Quality of Nursing Care respectively. Using a 2x2 factorial design and analysis of variance, the results indicated no significant gender influence on health locus of control, F (1,191) = 0.291, (p<0.05), a significant perception of quality of nursing care on health locus of control, F(1,191)= 14.184 = 0.0005 (p>0.05) and no significant interaction of gender and perception of Quality of Nursing Care on health locus of control F (1,191) = 0.024 P = 0.877 (P> 0.05). It is therefore recommended that hospital management should embark on training and retraining of health care workers in patient care relationships. Further study is also recommended in this areas especially on inpatient and out patients.